On April 21, 2022, David Daly, President and Chief Operating Officer of Singular Genomics Systems, Inc. (the “Company”), provided notice of his resignation from the Company to be effective on June 3, 2022 (the “Effective Date”). Mr. Daly intends to provide services through the Effective Date to assist in the transition of his duties. Drew Spaventa, the Company's Chief Executive Officer, will assume the additional role as President of the Company on the Effective Date.

The Company has no present intention to backfill the role of Chief Operating Officer.