Item 7.01 Regulation FD Disclosure.

On January 10, 2022, Singular Genomics Systems, Inc. (the "Company") posted an updated corporate presentation (the "Corporate Presentation") to its website, which the Company expects to use in presentations to investors, analysts and others. The Corporate Presentation may be accessed under the News & Events section of the Company's investor relations website at https://investor.singulargenomics.com/news-events/presentations.

The information in this Item 7.01 is being furnished and shall not be deemed "filed" for the purposes of Section 18 of the Securities Exchange Act of 1934, as amended ("Exchange Act"), or otherwise subject to the liabilities of that Section, and shall not be incorporated by reference into any registration statement or other document pursuant to the Securities Act of 1933, as amended, or the Exchange Act, except as otherwise expressly stated in such filing.

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