Shield Therapeutics : Investor presentations

Shield Therapeutics plc

('Shield' or the 'Group')

Investor presentations

London, UK, 24 January 2020: Shield Therapeutics plc (LSE: STX), a commercial stage, pharmaceutical company with a focus on addressing iron deficiency with its lead product Feraccru®/Accrufer® (ferric maltol), will be presenting at two investor presentations next month, providing an overview of the business and the progress being made by the Company.

Proactive One2One Biotech Forum

Tim Watts, Chief Financial Officer, will present at the Proactive One2One Biotech Forum on Thursday 6 February 2020 at the Chesterfield Mayfair Hotel, 35 Charles Street, Mayfair, W1J 5EB, starting from 6.00pm. The event brings together high net worth investors and private investors with an interest in growth stocks. Investors can register to attend the event here: https://www.proactiveinvestors.co.uk/register/event_details/235

The Growth & Innovation Forum 2020

Shield will have a stand and present at the Growth & Innovations Forum 2020, to be held on Tuesday 11 February at the Business Design Centre, 52 Upper Street, Islington, London, N1 0QH. This is a one-day investor event exhibiting companies focussed on growth and technology, attracting both institutional and retail investors. Investors can register to attend the event here: https://ajbell.eventsair.com/gif-2020/private/Site/Register

No new material information will be disclosed at either event and the presentations will be made available on the Company website shortly after the events here:https://www.shieldtherapeutics.com/investors/presentations

For further information please contact:

Shield Therapeutics plc	www.shieldtherapeutics.com
Carl Sterritt, Chief Executive Officer	[phone]
Tim Watts, Chief Financial Officer
Nominated Advisor and Broker
Peel Hunt LLP
James Steel/Dr Christopher Golden	[phone]
Joint Broker finnCap Ltd Geoff Nash/Matt Radley/Alice Lane	[phone]
Financial PR & IR Advisor
Walbrook PR	[phone] or [e-mail]
Paul McManus/Lianne Cawthorne	[phone] / [phone]

About Shield Therapeutics plc

Shield is a de-risked, commercial stage, specialty pharmaceutical company delivering innovative pharmaceuticals to address patients' unmet medical needs. The Company's clear purpose is to develop products that help patients become people again, enabling them to enjoy the things that make a difference in their everyday lives. The Group's lead product, Feraccru®/ Accrufer® has exclusive IP rights until the mid-2030s andis approved for the treatment of iron deficiency with or without anaemia in adultsin the European Union, the United States and Switzerland. In Europeit is marketed as Feraccru®with commercialisation led by Norgine BVand in the USA the productwill be marketed as Accrufer® with Shield currently in the process of selecting a commercialisation partner. Shield also has an exclusive licence agreement with Beijing Aosaikang Pharmaceutical Co. Ltd for the development and commercialisation of Feraccru®/Accrufer® in China, Hong Kong, Macau and Taiwan.

For more information please visit www.shieldtherapeutics.com

About Feraccru®/Accrufer®

Feraccru®/Accrufer® is a novel, stable, non-salt based oral therapyfor adults with iron deficiency with or without anaemia that has been shown to be an efficacious and well-tolerated therapy in a range of controlled phase 3 trials, including positive results fromthe Phase IIIb AEGIS-H2H study in which Feraccru®/Accrufer® demonstrated it was non-inferior in delivering improvements in haemoglobin levels compared tointravenously-administered (IV) Ferinject®/Injectafer® (ferric carboxymaltose). Feraccru®/Accrufer® therefore offers a compelling alternative to IV iron for those patients unable totolerate salt-based oral iron therapies and wish to avoid the complexities of infusion-based iron therapies.

When salt-based oral iron therapies are ingested they can cause a range of mild-to-severe gastrointestinal tract (GI) adverse events, including nausea, bloating and constipation through the release and subsequent reactivity of free iron in the GI tract, leading to poor tolerability, reduced patient compliance and ultimately treatment failure. Feraccru®/Accrufer® is not an iron saltand, as a result, it does not routinely cause the same treatment-limiting intolerance issues of salt-based iron therapies,whilst theiron from the ferric maltol molecule can be readily absorbed.

Prior to Feraccru®/Accrufer®, IV iron therapies were the only realistic alternative treatment option for iron deficient patientswith or without anaemiaintolerant of or unwilling to be treatedsalt-based oral iron therapies. However, use of such an invasive, costly, inconvenient and complex to administer treatment option, which is associated with potentially life-threatening and spontaneous hypersensitivity reactions, means there remains a clear unmet medical need for these patients to have access to an effective therapy that is well tolerated, convenient and does not require hospital-based administration. Feraccru®/Accrufer® meets those requirements.

About Iron Deficiency

The WHO states that iron deficiency is the most common and widespread nutritional disorder in the world. As well as affecting a large number of women and children in non-industrialized countries, it is the only nutrient deficiency which is also significantly prevalent in virtually all industrialised nations. There are no current global figures for iron deficiency but, using anaemia as an indirect indicator, it can be estimated that most preschool children and pregnant women in non-industrialised countries, together with at least 30-40% in industrialized countries, are iron deficient.

Forward-Looking Statements

This press release contains forward-looking statements. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements. These forward-looking statements are based on management's current expectations and include statements related to the commercial strategy for Feraccru®/Accrufer® These statements are neither promises nor guarantees, but involve known and unknown risks and uncertainties, many of which are beyond our control, that may cause actual results, performance or achievements to be materially different from management's expectations expressed or implied by the forward-looking statements, including, but not limited to, risks associated with, the Group's business and results of operations, competition and other market factors. The forward-looking statements made in this press release represent management's expectations as of the date of this press release, and except as required by law, the Group disclaims any obligation to update any forward-looking statements contained in this release, even if subsequent events cause our views to change.