Scancell : AGM Presentation 2022

DEVELOPING ANTIBODIES AND VACCINES FOR CANCER

ANNUAL GENERAL MEETING

Lindy Durrant, CEO

Sally Adams, CDO

November 22

LSE: SCLP.L

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Scancell AGM: November 22

2

Harnessing immunology to fight disease

USP: Targeting modified neo-antigens

Innovators in antibodies

and vaccines

• Clinical stage company with two vaccine technology platforms and three vaccine products in clinical development
• Two antibody technology platforms with a deep preclinical pipeline
• Licensing deal with Genmab for one of our five mAbs - milestones of up to $624m and single digit royalties

Specialist investor backing

and strong financial

position

• Supported by specialist biotech investors (Redmile Group, Vulpes)
• £82m raised to date, £33m in the last 2 years
• Cash runway to Q1 2024

Experienced team

• Experienced C-suite and board
• Expanding clinical development capability in-house to drive products forward
• Highly skilled team >50 employees headquartered in Oxford with research labs in Nottingham - have delivered four platforms creating multiple opportunities for proprietary projects and revenue- generating deals

Scancell AGM: November 22

3

Leveraging unique platforms to develop cutting edge products targeting modified neo-antigens

Four platforms delivering differentiated products for large unmet markets

ANTIBODIES	VACCINES
Targeting glycans preferentially expressed on tumours	Stimulating potent killer T cells

GlyMab®		AvidiMab®		Moditope®
Anti-glycan mAb x 4		Antibody AvidiMab®		Modi-1
Targeting pancreatic,		Broad potential for		Citrullination
colorectal, small cell lung		enhancing potency of any		Phase 1/2 trial in triple
(SCLC) and ovarian cancer		monoclonal antibody		negative breast (TNBC),
		(mAb)		ovarian, renal, head & neck
				cancer
Anti-glycan mAb x 1		Vaccine AvidiMab®		Modi-2
Stimulating tumour		Broad potential for		Homocitrullination
infiltrating T cells		enhancing potency of		Targeting breast, colorectal,
		vaccines		non-small cell lung (NSCLC),
				prostate cancer

ImmunoBody®

SCIB1/iSCIB1+

Phase 2 trial in melanoma

patients with immune checkpoint inhibitors

iSCIB1+ AvidiMab®

modified multi-epitope

vaccine

COVIDITY

Adapted for COVID-19 trial

Scancell AGM: November 22

4

Validation of the GlyMab® platform by leading antibody Biotech

• SC129 mAb licensed to Genmab for antibody drug conjugates (ADC), T cell bispecifics (TCB) and radioimmunotherapy
• Upfront and milestone payments
• Milestones totalling up to $624m, plus single digit royalties on sales
• Rights to SC129 for cell therapy products retained by Scancell

SC129 potential exemplified by internal and external preclinical studies

ADC activity in colorectal tumour model

• SC129 binds strongly to pancreatic and colorectal tumours and has low expression on normal tissues
• Strong ADC activity demonstrated in vivo
• Direct and bystander killing demonstrated
• Activities confirmed during assessment by Genmab

	6 0 0	Vehicle
)
3		Control RTX-ADC
(mm
	SC129-ADC
volume
4 0 0
Mean tumour	2 0 0
	0
	0	3	6	9	1 2	1 5	1 8	2 1	2 4	2 7	3 0

Study days

Tivadar et al., Mol Cancer Ther., 2020 Mar;19(3):790-801

Scancell AGM: November 22

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