Pharvaris recently presented data highlighting the unique pharmacological and clinical properties of deucrictibant for the treatment and prevention of HAE attacks at the 20th Annual Congress of International Drug Discovery Science and Technology (IDDST); the 2024 Eastern Allergy Conference (EAC); and the European Academy of Allergy and Clinical Immunology (EAACI) Congress 2024. In post-hoc analyses of the Phase 2 RAPIDe-1 clinical study data, resolution of HAE symptoms follow treatment with deucrictibant immediate-release capsule and placebo were measured using the Treatment Outcome Score (TOS) questionnaire for patient-reported outcomes (TOS PRO) and defined by the achievement of ?a lot better or resolved? in all symptom complexes.

Treatment with a single dose of oral deucrictibant resulted in the majority of HAE attacks achieving substantial symptom resolution (78.6% of participants with deucrictibant 20 mg [N=28] versus 22.4% of placebo [N=49]) within 24 hours. In addition to these findings, Pharvaris continues to evaluate the ever-changing treatment landscape in HAE to best address the unmet need of people living with HAE through presentation of real-world evidence of treatment behaviors. Evaluation of Treatment Satisfaction Questionnaire for Medication (TSQM) in participants in the Phase 2 CHAPTER-1 clinical study showed satisfaction with the effectiveness of deucrictibant is higher to placebo and is in-line with separate observations of high-efficacy injectables, while numerically more favorable than separate observations with other oral prophylactic therapies.

The side effects and convenience subdomain scores were consistent between deucrictibant and placebo; the global satisfaction score of deucrictibant is therefore driven by the high scores observed by the deucrictibant treating arms across all measured subdomains. Pharvaris remains committed to furthering understanding of other bradykinin-mediated diseases and the potential role that deucrictibant, as well as other therapeutic candidates from Pharvaris? platform, could play in improving the lives of people impacted by these diseases.