PDS Biotechnology Corporation announced that the initial safety data from its VERSATILE-002 study has been accepted for presentation at the 2022 Multidisciplinary Head and Neck Cancers Symposium being held February 24-26, 2022, at the JW Marriott Phoenix Desert Ridge Resort and Spa, Phoenix, AZ. The accepted abstract summarizes initial safety data from the ongoing Phase 2 study, being run in collaboration with Merck (known as MSD outside the US and Canada) (NCT04260126), which studies PDS0101 in combination with Merck's anti-PD-1 therapy KEYTRUDA® (pembrolizumab) for the treatment of recurrent or metastatic HPV16-positive head and neck cancer. It was previously announced that the trial had achieved its preliminary safety benchmark in the first 12 patients.

Abstract Number: 157; Abstract Title: Preliminary Safety of PDS0101 (Versamune® +HPVmix) and Pembrolizumab Combination Therapy in Subjects with Recurrent/Metastatic Human Papillomavirus-16 Positive Oropharyngeal Squamous Cell Carcinoma (OPSCC); Presenter:Jared Weiss, M.D., Associate Professor of Medicine, Division of Oncology at UNC School of Medicine, UNC Lineberger Comprehensive Cancer Center; PDS Biotech is also conducting a Phase 2 clinical study in both second- and third-line treatment of multiple advanced HPV-associated cancers with the National Cancer Institute (NCI). A third Phase 2 clinical trial in first-line treatment of locally advanced cervical cancer is being performed with The University of Texas, MD Anderson Cancer Center (IMMUNOCERV). KEYTRUDA® is a registered trademark of Merck Sharp & Dohme Corp., a subsidiary of Merck & Co.

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