Item 1.01 Entry into a Material Definitive Agreement.

Registered Direct Offering of Shares

On December 30, 2022, Palisade Bio, Inc. (the "Company") entered into securities purchase agreements (the "Purchase Agreements") with certain institutional and accredited investors (the "Purchasers"), pursuant to which the Company agreed to sell and issue, in a registered direct offering, an aggregate of (i) 476,842 shares (the "Shares") of the Company's common stock, par value $0.01 per share (the "Common Stock"), at a purchase price per share of $2.375, and (ii) registered prefunded warrants (the "Registered Prefunded Warrants") to purchase up to 37,000 shares of Common Stock at a purchase price of $2.3749 per Registered Prefunded Warrant (the "Registered Offering").

Each Registered Prefunded Warrant is exercisable immediately, has a perpetual term, an exercise price per share of Common Stock of $0.0001, and is subject to adjustment in the event of stock splits, dividends, subsequent rights offerings, pro rata distributions, and certain fundamental transactions, as more fully described in the Registered Prefunded Warrants. The Registered Prefunded Warrants do not contain any price protection provisions with respect to future securities offerings of the Company.

The Shares and Registered Prefunded Warrants (and shares underlying the Registered Prefunded Warrants) are being offered by the Company pursuant to an effective shelf registration statement on Form S-3, which was originally filed with the Securities and Exchange Commission (the "SEC") on March 18, 2022, as amended, and was declared effective on April 26, 2022 (File No. 333-263705) (the "Registration Statement") and a prospectus supplement thereunder.

A copy of the opinion of the Silvestre Law Group, P.C. relating to the validity of the Shares of Common Stock and Registered Prefunded Warrants issued in the Registered Direct Offering is filed herewith as Exhibit 5.01.

Concurrent Private Placements

Private Placement of Prefunded Warrants

In addition to the sale of Shares and Registered Prefunded Warrants, pursuant to the Purchase Agreements, the Company also issued certain Purchasers, subject to certain beneficial ownership limitations, unregistered prefunded warrants to purchase up to 538,789 shares of Common Stock (the "Unregistered Prefunded Warrants") with the same terms as the Registered Prefunded Warrants except that the Unregistered Prefunded Warrants are not registered pursuant to the Registration Statement (the "Concurrent Prefunded Warrant Private Placement").

Private Placement of Common Stock Purchase Warrants

Pursuant to the Purchase Agreements, in a concurrent private placement, the Company has also agreed to sell and issue to each Purchaser that purchased any (i) Shares, (ii) Registered Prefunded Warrants, and / or (iii) Unregistered Prefunded Warrants, warrants to purchase such number of shares of Common Stock equal to the number of Shares, Registered Prefunded Warrants or Unregistered Prefunded Warrants that a Purchaser purchased pursuant to the Purchase Agreement (the "Private Warrants"). In aggregate, pursuant to the Purchase Agreements, the Company will issue Private Warrants to purchase up to 1,052,631 shares of Common Stock, each with a per share exercise price of $2.375 (the "Concurrent Warrant Private Placement"). The Private Warrants are exercisable immediately and expire five (5) years from the date of issuance. The Private Warrants are subject to adjustment in the event of stock splits, dividends, subsequent rights offerings, pro rata distributions, and certain fundamental transactions, as more fully described in the Private Warrants. The Private Warrants do not contain any price protection provisions with respect to future securities offerings of the Company.

The Purchase Agreements contain customary representations, warranties and agreements by the Company, customary conditions to closing, indemnification obligations of the Company, including for liabilities arising under the Securities Act of 1933, as amended (the "Securities Act"), other obligations of the parties, and termination provisions. The representations, warranties and covenants contained in the Purchase Agreements were made only for the purposes of such agreement and as of the specific dates, were solely for the benefit of the parties to such agreement and may be subject to limitations agreed upon by the contracting parties.

The Registered Offering, the Concurrent Prefunded Warrant Private Placement, and the Concurrent Warrant Private Placement (collectively together, the "Offering") is expected to close on or about January 4, 2022, subject to customary closing conditions for aggregate gross proceeds to the Company of approximately $2.5 million, before deducting fees payable to the placement agent and other estimated offering expenses payable by the Company.

The Unregistered Prefunded Warrants, the Private Warrants, and the shares of Common Stock issuable upon exercise of the Unregistered Prefunded Warrants and Private Warrants (collectively, the "Warrant Shares") have not been registered under the Securities Act pursuant to the Registration Statement and are instead being offered pursuant to the exemption provided in Section 4(a)(2) under the Securities Act and Rule 506(b) promulgated thereunder. In connection with each Purchaser's execution of a Purchase Agreement, each such Purchaser represented to the Company that it is either an "accredited investor" as defined in Rule 501(a)(1), (a)(2), (a)(3), (a)(7), (a)(8), (a)(9), (a)(12) or (a)(13) under the Securities Act or (ii) a "qualified institutional buyer" as defined in Rule 144A(a) under the Securities Act, among other items.

The Company also entered into a registration rights agreements with the Purchasers, whereby the Company agreed to file a registration statement on Form S-3 within 30 days of the closing of the Offering, which shall provide for the resale by holders of the Warrants Shares and to have such registration statement declared effective by February 14, 2023, and to use best efforts to keep such registration statement effective at all times until such date that the Warrant Shares either (i) have been sold, or (ii) may be sold without volume or manner-of-sale restrictions pursuant to Rule 144 and without the requirement for the Company to be in compliance with the current public information requirement under Rule 144.

The closing of the Offering is subject to satisfaction of customary closing conditions set forth in the Purchase Agreements. The representations, warranties and covenants contained in the Purchase Agreements were made solely for the benefit of the parties to the Purchase Agreements. In addition, such representations, warranties and covenants (i) are intended as a way of allocating the risk between the parties to the Purchase Agreements and not as statements of fact, and (ii) may apply standards of materiality in a way that is different from what may be viewed as material by stockholders of, or other investors in, the Company. Accordingly, the Purchase Agreements are filed with this report only to provide investors with information regarding the terms of transaction, and not to provide investors with any other factual information . . .

Item 3.02 Unregistered Sales of Equity Securities

The disclosure set forth in Item 1.01 of this Current Report on Form 8-K to the extent required by this Item 3.02 is incorporated herein by reference.




Item 8.01 Other Events



On December 30, 2022, the Company issued a press release announcing the various transactions described herein. A copy of the press release is attached as Exhibit 99.01 hereto.

On January 4, 2023, the Company issued a press release announcing the closing of the transactions described herein. A copy of the press release is attached as Exhibit 99.02 hereto.

Item 9.01 Financial Statement and Exhibits.






Exhibit
No.                                     Description
4.01        Form of Registered Prefunded Warrant
4.02        Form of Unregistered Prefunded Warrant
4.03        Form of Common Stock Warrant
4.04        Form of Placement Agent Warrant
5.01        Legal Opinion of Silvestre Law Group, P.C.
10.01       Form of Securities Purchase Agreement
10.02       Form of Registration Rights Agreement
10.03       Form of Placement Agent Agreement
23.01       Consent of the Silvestre Law Group, P.C. (included in Exhibit 5.01)
99.01       Press Release dated December 30, 2022
99.02       Press Release dated January 4, 2023
104       Cover Page Interactive Data File (embedded within the Inline XBRL
          document)

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