TissueGen Inc. announced that its patented extrusion technology enables absorbable fibers to be loaded with a wider variety of drugs and biologically-based entities than ever previously possible. The company is partnering with Biomedical Structures LLC to develop a finished textile platform for drug-eluting medical device applications such as small diameter vascular grafts and stents, tissue and nerve regeneration, orthopedics, and sutures using TissueGen's patented drug delivery technology. TissueGen's proven technology is purpose-built for advanced drug delivery and sustained therapeutic release.

Its core technology includes fiber extrusion at room temperature, which preserves the biological activity of incorporated drugs and therapeutic agents. This enables drug delivery through biodegradable fibers -- a groundbreaking format that drastically expands the types of agents that can be directly incorporated into implantable medical devices. For the first time, device developers can take advantage of the sophisticated drug-delivery capabilities of fibers incorporating high levels of manufacturing tolerance to provide tailored release kinetics for in vivo support and regeneration applications.

Designed for custom tunability of release profiles and capabilities, this unique biomaterial format is used across a wide variety of therapeutics and can be engineered for any biologic therapeutic from small pharmaceuticals to protein class drugs such as enzymes, and growth factors, even large viral particles. Drugs are incorporated into the fiber according to device performance requirements using a combination of commercially available polymer components, including PLLA and PDO.