Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

On March 4, 2022, Jerald Korn, the General Counsel and Chief Operating Officer of Kaleido Biosciences, Inc. (the "Company"), submitted notice to the Company of his resignation, effective March 18, 2022, to pursue another opportunity. The Company will be entering into a consulting agreement with Mr. Korn pursuant to which Mr. Korn will provide general administrative and other corporate services to the Company through April 30, 2022. The Company thanks Mr. Korn for his contributions.

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