The current study assessed the feasibility of delivering Affilogic’s anti-viral affinity proteins – Nanofitins® – against SARS-CoV-2 to the lung using Iconovo’s dry powder single-dose inhaler ICOone®. Results confirmed that Nanofitins® can be formulated as a spray-dried powder for inhaled delivery and delivered by ICOone® with maintained activity and a fine particle fraction suitable for pulmonary delivery.
“We are very pleased with the results showing that Nanofitins can be delivered successfully to the lung using ICOone®. This possibility broadens the horizon to include new and innovative treatment strategies against viral and bacterial infections with the potential to play an important role in future pandemic response,” says Johan Wäborg, CEO of
“Our Nanofitins® are 20 times smaller than antibodies, highly soluble and extremely stable proteins, we anticipated that formulating them for inhalation would be feasible but we did not expect Iconovo’s results with ICOone® to be so convincing from the very first test” says
The results will be presented in full in a poster with the title “Novel inhaled anti-viral against SARS-CoV-2: Feasibility of developing a Nanofitin dry powder formulation for pulmonary delivery using the ICOone® single dose dry powder inhaler”, at the conference Respiratory Drug Delivery, RDD 2024
About RDD 2024
Respiratory Drug Delivery (RDD®) 2024 will be held at the
About Nanofitins®
For any biological target, from peptides to entire cells, it is possible to generate custom Nanofitins® with a high binding affinity and controlled specificity for targeting or interacting purposes. They can thereby be designed as targeted inhibitors, mostly as a fusion of several Nanofitins® for multispecificity, or as vectors for specific transport of a third-party molecule (experience with enzymes, peptides, nanoparticles, radionuclides, cytotoxic payload, nucleic acids, CAR-T). Usual systemic routes can be traveled by Nanofitins® but their intrinsic properties make them amenable to other routes, such as pulmonary delivery.
About Affilogic
Affilogic is an independent private company established in Nantes,
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