Effective March 2, 2022, the GT Biopharma, Inc. (Registrant) appointed Michael Breen as the Registrant's Interim Chief Executive Officer with an increase in his annual base compensation to $515,000. Gregory Berk, M.D. ceased serving as the Registrant's Interim Chief Executive Officer, but will continue to serve as the Registrant's President of Research & Development and Chief Medical Officer, with a cost-of-living increase in his annual base compensation to $437,750.