Item 3.01 Material Modification to Rights of Security Holders.

To the extent required by Item 3.03 of Form 8-K, the information regarding the Reverse Stock Split (as defined below) contained in Item 5.03 of this Current Report on Form 8-K is incorporated by reference herein.

Item 5.03 Amendments to Articles of Incorporation or Bylaws; Change in Fiscal


          Year.



On August 25, 2022, First Wave BioPharma, Inc. (the "Company" or "First Wave") announced that it intends to effect a reverse stock split (the "Reverse Stock Split") of its issued and outstanding common stock (the "Common Stock") at a ratio of 1 post-split share for every 30 pre-split shares. First Wave's Common Stock will continue to be traded on The Nasdaq Capital Market under the symbol FWBI and will begin trading on a split-adjusted basis when the market opens on Friday, August 26, 2022, under a new CUSIP number, 33749P200.

At the annual meeting of stockholders held on August 25, 2022, First Wave's stockholders granted the Company's Board of Directors (the "Board") the discretion to effect a reverse stock split of First Wave's Common Stock through an amendment (the "Amendment") to its Certificate of Incorporation, as amended and restated to date (the "Charter"), at a ratio of not less than 1-for-10 and not more than 1-for-40, such ratio to be determined by the Board.

On August 25, 2022, the Company filed the Amendment for the Reverse Stock Split with the Secretary of State of the State of Delaware, and the Reverse Stock Split will become effective in accordance with the terms of the Amendment at 12:01 AM Eastern Time on August 26, 2022 (the "Effective Time").

At the Effective Time, every thirty shares of First Wave's issued and outstanding Common Stock will be converted automatically into one issued and outstanding share of Common Stock, with no corresponding reduction in the number of authorized shares of Common Stock, and without any change in the par value per share. Stockholders holding shares through a brokerage account will have their shares automatically adjusted to reflect the 1-for-30 Reverse Stock Split. It is not necessary for stockholders holding shares of the Common Stock in certificated form to exchange their existing stock certificates for new stock certificates of the Company in connection with the Reverse Stock Split, although stockholders may do so if they wish.

The Reverse Stock Split will affect all stockholders uniformly and will not alter any stockholder's percentage interest in the Company's equity, except to the extent that the Reverse Stock Split would result in a stockholder owning a fractional share. No fractional shares will be issued in connection with the Reverse Stock Split. Stockholders who would otherwise be entitled to receive a fractional share will instead receive a cash payment based on the closing price of the Common Stock as reported on The Nasdaq Capital Market on August 25, 2022. The Reverse Stock Split will reduce the number of shares of Common Stock outstanding from approximately 42 million shares to approximately 1.4 million shares. Proportional adjustments will be made to the number of shares of Common Stock issuable upon exercise or conversion of First Wave's equity awards, convertible preferred stock and warrants, as well as the applicable exercise price. Stockholders with shares in brokerage accounts should direct any questions concerning the Reverse Stock Split to their broker; all other stockholders may direct questions to the Company's transfer agent, Colonial Stock Transfer, at 801-355-5740.

The foregoing description of the Amendment does not purport to be complete and is qualified in its entirety by reference to the full text of the Amendment, which is filed as Exhibit 3.1 to this Current Report on Form 8-K and incorporated by reference herein.

Item 5.07 Submission of Matters to a Vote of Security Holders.

On August 25, 2022, the Company held an annual meeting of stockholders (the "Annual Meeting"). The matters voted on at the Annual Meeting were the following proposals: (1) the election of directors, (2) the adoption and approval of an amendment to the Charter to effect a reverse stock split of the Company's issued and outstanding shares of Common Stock at a specific ratio, ranging from one-for-ten (1:10) to one-for-forty (1:40), at any time prior to the one-year anniversary date of the Annual Meeting, with the exact ratio to be determined by the Board without further approval or authorization of the Company's stockholders, (3) the approval, on an advisory basis, of the exeutive compensation of the Company's named executive officers, (4) indication, on an advisory basis, of the preferred frequency of stockholder advisory votes on the compensation of the Company's named executive officers, and (5) the approval of the adjournment of the Annual Meeting to the extent there are insufficient proxies at the Annual Meeting to approve any one or more of the foregoing proposals

At the Annual Meeting, all five of the foregoing stockholder proposals were approved, based upon an aggregate of 41,590,308 shares of Common Stock, 150 shares of Series D Preferred Stock and 150 shares of Series E Preferred Stock outstanding as of July 15, 2022, which was the record date for the Annual Meeting. The final voting results were as follows:





1.     The election of each of James Sapirstein, Edward J. Borkowski, Charles J.
       Casamento, Terry Coelho, David Hoffman and Alastair Riddell as directors
       to hold office for a term of one year, until his or her successor is duly
       elected and qualified or he or she is otherwise unable to complete his or
       her term.



The votes were cast for this matter as follows:





      Nominees         Votes For    Votes Withheld   Broker Non-Votes
James Sapirstein       3,123,370      1,322,525        10,224,308
Edward J. Borkowski    3,131,149      1,314,746        10,224,308
Charles J. Casamento   3,149,717      1,296,178        10,224,308
Terry Coelho           3,146,281      1,299,614        10,224,308
David Hoffman          3,118,818      1,327,077        10,224,308
Alastair Riddell       3,147,928      1,297,967        10,224,308




2.     The proposal to adopt and approve an amendment to the Charter to effect a
       reverse stock split of the Company's issued and outstanding shares of
       Common Stock, at a specific ratio, ranging from one-for-ten (1:10) to
       one-for-forty (1:40), at any time prior to the one-year anniversary date
       of the Annual Meeting, with the exact ratio to be determined by the Board
       was approved by a majority of the voting power of the outstanding shares
       of Common Stock, Series D Preferred Stock and Series E Preferred Stock
       entitled to vote on the proposal, based upon the following votes:




  Votes For      Votes Against   Abstentions
22,716,528,871   7,298,877,910     14,549




3.     The proposal to approve, on an advisory basis, the executive compensation
       of the Company's named executive officers was approved by a majority of
       votes cast, based upon the following votes:




Votes For   Votes Against   Abstentions   Broker Non-Votes
2,518,382    1,706,052       221,461        10,224,308




4.     The proposal to indicate, on an advisory basis, the preferred frequency of
       stockholder advisory votes on the compensation of the Company's named
       executive officers was approved by a majority of votes cast, based upon
       the following votes:




  1 Year     2 Years   3 Years    Abstain
3,452,479    93,307    413,074    487,035




5.     The proposal to approve the adjournment of the Annual Meeting to the
       extent that there are insufficient proxies at the Annual Meeting to
       approve any one or more of the foregoing proposals was approved by a
       majority of votes cast, based upon the following votes:




Votes For    Votes Against   Abstentions
12,065,061     2,417,662       187,480



The Board has considered the outcome of Proposal 4, the advisory vote on how often the Company will conduct an advisory vote on executive compensation and has determined, as was recommended with respect to this proposal by the Board in the proxy statement for the Annual Meeting, that the Company will conduct future advisory votes on executive compensation every year until the occurrence of the next vote on how often the Company will conduct an advisory vote on executive compensation. The next vote, on an advisory basis, on how often the Company will conduct an advisory vote on executive compensation is required to occur no later than the Company's 2028 Annual Meeting of Stockholders.

Item 7.01 Regulation FD Disclosure.

On August 25, 2022, the Company issued a press release announcing the Reverse Stock Split, a copy of which is furnished as Exhibit 99.1 to this Current Report on Form 8-K.

Item 9.01 Financial Statements and Exhibits.






  (d) Exhibits.




Exhibit No.   Description
                Certificate of Amendment to the Amended and Restated Certificate of
  3.1         Incorporation of First Wave BioPharma, Inc., dated August 25, 2022.
  99.1          Press Release, dated August 25, 2022
              Cover Page Interactive Data File (embedded within the Inline XBRL
104           document).

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