Dova Pharmaceuticals presented data on the cost effectiveness of Doptelet (avatrombopag) for the treatment of thrombocytopenia in patients with chronic liver diseases (CLD) who are scheduled to undergo a procedure at the 61st Annual Meeting of the American Society of Hematology (ASH) taking place in Orlando, 7-10 December. Patients with CLD often have severe thrombocytopenia (platelet counts <50,000/µL) that can complicate the invasive diagnostic and therapeutic procedures these patients require as part of their clinical management, due to the increased bleeding risk. Doptelet is a thrombopoietin receptor agonist (TPO-RA) that is approved for the treatment of thrombocytopenia in adult patients with CLD as an alternative to platelet transfusions for patients undergoing a procedure. The aim of the study was to evaluate the relative cost-effectiveness of avatrombopag compared with platelet transfusion or treatment with lusutrombopag, another TPO-RA also approved for the treatment of thrombocytopenia in adult patients with CLD. In the overall population, avatrombopag reduced the need for platelet transfusions and produced cost-savings per person compared to intended platelet transfusion (80% fewer prophylactic platelet transfusions), resulting in a relative cost savings of USD 4,250. The cost for lusutrombopag (15% more platelet transfusions) relative to avatrombopag was USD 5,819 higher than the cost of avatrombopag. The one-way and probabilistic sensitivity analyses showed that the use of avatrombopag remained cost-saving over a wide range of changes, with incremental cost-effectiveness including decreased costs and importantly, avoiding prophylactic platelet transfusions.