On and effective December 16, 2020, Amy Schulman resigned from the board of directors of Cyclerion Therapeutics, Inc. On December 16, 2020, the Company appointed Cheryl Gault, the Company's current Vice President, Strategy and Corporate Development, to be the Company's Chief Operating Officer, effective January 1, 2021. Ms. Gault joined the Company upon inception, originally as Vice President, Head of Strategy and, since May 2020, as Senior Vice President, Strategy & Corporate Development. Immediately prior thereto, Ms. Gault held various positions at Ironwood. Ms. Gault's positions at Ironwood included, most recently from February 2017, as Vice President, Commercial Strategy & New Product Planning, and, prior thereto from February 2011, in various new product planning and brand positions.