Certara, Inc. announced the release of version 20 of its Simcyp™ Physiologically-based Pharmacokinetic (PBPK) Simulator platform. Simcyp PBPK Simulator version 20 provides new models for maternal health, virtual bioequivalence to attain biowaivers, and analysis of long-acting injectable drugs. It also delivers a newly expanded biologics module, Simcyp Biologics Simulator, that enables scientists to model a wider range of biologic modalities to accelerate drug development. Certara’s industry-leading Simcyp PBPK Simulator improves clinical trial efficiency and outcomes through the modeling and simulation of pharmacokinetics (PK) and pharmacodynamics (PD) using virtual patient populations. The Simcyp PBPK Simulator’s in silico models have informed the label claims of more than 75 novel FDA-approved drugs, reducing the need to conduct human clinical studies. This mechanistic modeling approach, developed over the past 20 years, is well established in predicting the PK of small molecules and is now increasingly being applied to biologic drug development. Simcyp PBPK Simulator version 20 offers new and enhanced models for maternal health, such as assessing drug performance during pregnancy and lactation. It also automates the assessment of virtual bioequivalence to attain biowaivers and analyzes drugs delivered via long-acting injectable delivery. Additional upgrades have been made to the Simcyp PBPK Simulator’s animal, liver, absorption, and skin models.