Asarina Pharma AB (publ) announced that Sepranolone suppresses tics in Tourette Syndrome and restores Prepulse Inhibition. The new data also point towards the overproduction of Allopregnanolone in acute stress situations as potentially crucial in triggering negative symptoms in neuropsychiatric conditions from Tourette to OCD, mania and schizophrenia. THE FIRST SET OF FINDINGS is from a newly developed mouse model of TS, developed to confirm 2019 data from a previous D1CT-7 transgenic mouse model. The new model was generated through early-life depletion of cholinergic interneurons in the striatum, an abnormality observed in post-mortem brain samples of individuals affected by TS. The mice subjected to this manipulation in early adolescence develop increased stress-induced stereotypes and gating impairments, which were mediated by Allopregnanolone and significantly suppressed by Sepranolone. THE SECOND SET OF FINDINGS were from mouse and rat models that measured the effect of the overproduction of Allopregnanolone on PPI. PPI is a highly reliable index that measures ability to filter out redundant information. It is commonly used in preclinical tests in a range of psychiatric disorders.