Artelo Biosciences, Inc. announced several presentations about ART12.11, Artelo's proprietary cocrystal combination drug candidate, were delivered at the 34th Annual International Cannabinoid Research Society (ICRS) Symposium held June 30 through July 5, 2024 in Salamanca, Spain. Rodent pharmacokinetic data demonstrated that oral administration of an aqueous suspension of ART12.11 leads to increased plasma levels of CBD and its metabolites compared to CBD in the same formulation. This pharmacokinetic profile could not be replicated with coadministration of CBD and TMP.

Furthermore, orally administered ART12.11 demonstrated similar plasma levels of CBD and its metabolites as an Epidiolex-like formulation in fed rodents. These results were obtained with an unoptimized aqueous suspension of ART12.11. Artelo is currently conducting drug formulation studies in order to optimize the oral solid delivery of ART12.11.

In the pharmacodynamic study performed at the laboratory of Dr. Laviolette, oral administration of ART12.11 significantly reduced a range of anxiety and depressive symptoms in chronically stressed rats. These effects were not significantly observed with either Cannabidiol (CBD) or Tetramethylpyrazine (TMP) administered alone, or with a co-administration of CBD and TMP, despite CBD dosed alone with three times the amount of CBD used contained in ART12.11.