Item 8.01. Other Events.

On February 27, 2023, Aptinyx Inc. issued a press release titled "Aptinyx Reports Results from Phase 2 Study of NYX-458 in Cognitive Impairment Associated with Parkinson's Disease and Dementia with Lewy Bodies and Provides Pipeline and Corporate Update." A copy of the press release is attached hereto as Exhibit 99.1 and is incorporated herein by reference.

Item 9.01. Financial Statements and Exhibits.





(d) Exhibits



Exhibit No.                                Description
  99.1          Press release issued by Aptinyx Inc. on February 27, 2023, furnished
              herewith
104           Cover Page Interactive Data File




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