Akcea Therapeutics, Inc. announced that the Main Association of Austrian Social Security Institutions has granted approval for the national reimbursement of TEGSEDI® (inotersen) for the treatment of stage 1 or stage 2 polyneuropathy in adult patients with hereditary transthyretin (hATTR) amyloidosis. hATTR amyloidosis is an under-recognized, debilitating and progressive disease that is caused by the buildup of transthyretin (TTR) proteins that misfold due to inherited genetic mutations. It is characterized by the deposition of amyloid fibrils throughout the body including in nervous tissue and can have a devastating impact on patients' quality of life. TEGSEDI is a once-weekly, at-home subcutaneous injection that targets the polyneuropathy of hATTR amyloidosis at its source by silencing the defective gene in these patients and reducing production of the abnormal TTR protein. It is the first antisense oligonucleotide medicine available for patients in Austria with hATTR amyloidosis with polyneuropathy and also the first treatment available that can be self-administered in the comfort of their own home. The positive reimbursement recommendation for TEGSEDI issued by the Main Association of Austrian Social Security Institutions was based on results from the Phase 3 NEURO-TTR study of the therapy in patients with hATTR amyloidosis with symptoms of polyneuropathy. Data from the study showed that patients treated with TEGSEDI experienced significant benefit compared to patients treated with placebo across both co-primary endpoints: the Norfolk Quality of Life Questionnaire-Diabetic Neuropathy (Norfolk QoL-DN) and modified Neuropathy Impairment Score +7 (mNIS+7), a measure of neuropathic disease progression.