On October 15, 2019, Stephen Hoffman departed his positions as Chief Executive Officer of Aerpio Pharmaceuticals, Inc. and as principal executive officer of the Company, effective immediately. On October 15, 2019, Dr. Hoffman also resigned as a director of the Company, effective immediately. On October 15, 2019, Michael Rogers departed his positions as Chief Financial and Business Officer of the Company and as principal financial officer and principal accounting officer of the Company, effective immediately.

On October 15, 2019, the Company appointed Joseph Gardner, the Company's current President and Founder, as the Company's principal executive officer on October 15, 2019, effective immediately. No change is currently anticipated in Dr. Gardner's compensatory arrangement with the Company as a result of his appointment as the Company's principal executive officer. Additionally, there are no arrangements or understandings between Dr. Gardner and any other persons pursuant to which he was selected as the Company's principal executive officer.

Dr. Gardner has no family relationship with any of the executive officers or directors of the Company. On October 15, 2019, the Company appointed Regina Marek, the Company's current Vice President of Finance, as the Company's principal financial officer and principal accounting officer, effective immediately. Regina Marek has served as the Company's Vice President of Finance since August 2018.

From July 2014 to July 2018, Ms. Marek served as vice president, corporate controller and vice president, integration for Milacron. From 2012 to 2014, Ms. Marek was vice president of internal audit at Macy's and, prior to that she held multiple roles at Owens Corning from 2005 to 2012 including controller of the residential insulation business and director of internal audit for the global composites business. Ms. Marek started her career at Ernst & Young in Cleveland and worked as an auditor and senior manager in the transaction advisory service practice group.