ITEM 5.02 Departure of Directors or Certain Officers; Election of Directors;

Appointment of Certain Officers; Compensatory Arrangements of Certain

Officers.

(b) On January 7, 2021, Amy Pott notified the Board of Directors (the "Board") of Wave Life Sciences Ltd. (the "Company") of her resignation from the Board and the compensation committee thereof, effective as of January 8, 2021. Her resignation resulted from having accepted a new position at Audentes Therapeutics, an Astellas company, and potential conflicts of interest therewith. Her resignation did not result from any disagreement with the Company on any matter relating to the Company's operations, policies, practices or otherwise.

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