Genenta Science announced that preliminary findings from its Phase 1/2a of Temferon™ in the treatment of patients with glioblastoma multiforme patients who have an unmethylated MGMT gene promoter (uMGMT-GBM) provide initial evidence of Temferon's potential for modulating the tumor microenvironment as well as details of Temferon's continuing positive safety profile and signals of biological activity. The findings will be given as an oral presentation at the forthcoming 25th annual meeting of the American Society of Gene and Cell Therapy (ASGCT) to be held in Washington. D.C., May 16-19, 2022.

Fifteen patients have been dosed with up to 2.0x106 Temferon™ cells/kg. Based on the persistence of cells in the peripheral blood and bone marrow up to 18 months the company concludes that Temferon successfully engrafts, and no drug-limiting toxicities have been identified. The ability of Temferon cells to find their way from bone marrow to the tumor site is supported by the presence of gene-marked cells in the tumor resected specimens of the 3 out of the 4 patients who underwent routine 2nd surgical procedures.

A ‘Temferon signature' – markers of interferon-alpha responses and macrophage repolarization – was also highlighted in Temferon-treated patients compared to patients who received current standard-of-care for GBM.