Recce Pharmaceuticals doses highest cohort in phase I/II UTI/Urosepsis trial
May 17, 2024 at 12:11 am IST
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Recce Pharmaceuticals Ltd (ASX:RCE, OTC:RECEF) managing director and CEO James Graham talks with Proactive’s Jonathan Jackson about how Recce has administered the first doses in the latest cohort of its Phase I/II clinical trial for urinary tract infection (UTI) and urosepsis treatment with RECCE® 327 (R327). Both male and female participants received R327 at 4,000mg intravenously (I.V.) over 20 minutes, marking the highest dosage in this trial to date. R327, an intravenous and topical therapy, is being developed to treat serious infections caused by Gram-positive and Gram-negative bacteria, including their superbug forms. The clinical trial has explored various infusion times for R327, including 15, 20, 30 and 45 minutes, across different dosage levels. This latest cohort involves the highest dose of 4,000mg, with Minimum Inhibitory Concentration (MIC) activity against bacteria identified in existing clinical samples. This dose optimisation is significant for regulatory purposes. Remaining participants will be dosed in the coming days, and the full potential of R327 via I.V. administration will be evaluated upon completion of the trial.
Contact Details
Proactive Investors
Jonathan Jackson
+61 413 713 744
jonathan@proactiveinvestors.com
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Recce Pharmaceuticals Ltd is an Australia-based company engaged in the development and commercialization of a new class of synthetic anti-infectives designed to address the urgent global health problems of antibiotic-resistant superbugs and emerging viral pathogens. The Companyâs anti-infective pipeline includes three broad-spectrum, synthetic polymer anti-infectives: RECCE 327 as an intravenous and topical therapy that is being developed for the treatment of serious and potentially life-threatening infections due to Gram-positive and Gram-negative bacteria including their superbug forms; RECCE 435 as an orally administered therapy for bacterial infections; and RECCE 529 for viral infections. Through their multi-layered mechanisms of action, the Companyâs anti-infectives have the potential to overcome the hypercellular mutation of bacteria and viruses. All RECCE compounds are 100% water soluble at all pH levels in their liquid form.
RECCE PHARMACEUTICALS LTD 
