Piazza Affari opened the week in the red as market sentiment soured over skyrocketing crude prices, fueled by escalating conflict in Iran and production cuts from major Middle Eastern exporters.

The oil rally, with prices breaching the $100-a-barrel mark, has sparked deep concerns over an inflationary shock that could severely strain global economic growth.

European indices followed a sharp downturn in Tokyo, where the Nikkei plunged over 5%, while U.S. futures are trading down by more than 1.5%.

By 9:35 a.m., Milan's benchmark FTSE Mib index was down 2.2%, slipping below the 43,000-point threshold for the first time since early December.

Banking stocks are in freefall, averaging a 3.2% loss, with UNICREDIT down 3.6%, MPSI shedding 3.5%, and INTESA dropping 3.4%.

The sell-off has spared few sectors, with industrials and utilities also facing heavy pressure.

Among the few bright spots, NEXI is attempting a rebound, gaining 4%. Morgan Stanley upgraded the payments firm to 'equal weight' from 'underweight' following a sharp decline in the final sessions of last week.

LOTTOMATICA is also performing well, up 1.1% after Barclays raised its target price to 31 euros from 26 euros.

LEONARDO is losing momentum despite an upgrade by Barclays to 'overweight' from 'equal-weight'.

(Andrea Mandala, editing Claudia Cristoferi)