JJaguar Health, Inc. entered into a securities purchase agreement with new investor Brown Stone Capital, LTD for issuance of 161,583 common shares at a price of $1.56 per share for gross proceeds of $252,069.48; and 479,442 pre-funded warrants at a price of $1.5599 per warrant for gross proceeds of $747,881.5758; for aggregate gross proceeds of $999,951.0558 on September 28, 2025. The Securities were offered and sold in reliance upon exemptions from registration pursuant to Section 4(a)(2) under the Securities Act of 1933, as amended (the ? Securities Act ?), and Rule 506 of Regulation D promulgated thereunder.